Hypoxia-inducible factors in cancer stem cells and inflammation
نویسندگان
چکیده
منابع مشابه
Hypoxia-Inducible Factors, Stem Cells, and Cancer
Regions of severe oxygen deprivation (hypoxia) arise in tumors due to rapid cell division and aberrant blood vessel formation. The hypoxia-inducible factors (HIFs) mediate transcriptional responses to localized hypoxia in normal tissues and in cancers and can promote tumor progression by altering cellular metabolism and stimulating angiogenesis. Recently, HIFs have been shown to activate specif...
متن کاملHypoxia-inducible factors in stem cells and cancer
Cellular properties are influenced by complex factors inherent to their microenvironments. While oxygen deprivation (hypoxia) occurs in tumours because of rapid cell proliferation and aberrant blood vessel formation, embryonic cells develop in a naturally occurring hypoxic environment. Cells respond to hypoxia by stabilizing hypoxia-inducible factors (HIFs), which are traditionally viewed to fu...
متن کاملHypoxia-inducible factors: a central link between inflammation and cancer.
The tumor immune response is in a dynamic balance between antitumor mechanisms, which serve to decrease cancer growth, and the protumor inflammatory response, which increases immune tolerance, cell survival, and proliferation. Hypoxia and expression of HIF-1α and HIF-2α are characteristic features of all solid tumors. HIF signaling serves as a major adaptive mechanism in tumor growth in a hypox...
متن کاملHypoxia - inducible factors : a central link between inflammation and cancer
Introduction The tumor microenvironment is similar to an inflammatory focus, as it consists of a complex milieu of both innate and adaptive immune cells (1). Hypoxia is a characteristic feature of both tumors and inflammatory foci. Increased metabolic demand from rapid cell turnover, immune cell infiltration, and vascular disruption cause local O2 tension to decline. The decreased O2 tension of...
متن کاملHypoxia-inducible factors: key regulators of myeloid cells during inflammation.
Hypoxia is a prominent characteristic of many acute or chronic inflammatory diseases, and exerts significant influence on their progression. Macrophages and neutrophils are major cellular components of innate immunity and contribute not only to O2 deprivation at the site of inflammation, but also alter many of their functions in response to hypoxia to either facilitate or suppress inflammation....
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ژورنال
عنوان ژورنال: Trends in Pharmacological Sciences
سال: 2015
ISSN: 0165-6147
DOI: 10.1016/j.tips.2015.03.003